genOway preclinical models -

Models with humanised Immune Checkpoints (ICP)

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Mice expressing humanised Immune Checkpoints (ICPs) to evaluate immunotherapies in a physiological microenvironment.

Cells with humanised or KO Immune Checkpoints (ICP)

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Cell lines expressing humanised Immune Checkpoints (ICP), with knock-out of the murine gene allowing the study of tumour growth in vivo (grafting) and in vitromechanics.

BRGSF and BRGSF-HIS murine models

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Immunodeficient and reconstituted models. Immunodeficient mice without myeloid compartments and murine lymphoid , which can be reconstituted with a complete and functional human immune system.

Dual humanised hSA/hFcRn murine models

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Models for pharmacokinetic (PK/PD) studies. Mice expressing human serum albumin (hSA) and neonatal Fc receptor (hFcRN) with maintenance of autologous receptor-ligand interaction for PK/PD studies in a physiological context.

Models with humanised T-cell engagers

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Mice expressing humanised T-cell engagers to evaluate immunotherapies in a physiological microenvironment.

genOway humanised murine models of allergy and inflammation

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Mice expressing key humanised therapeutic targets in the study of inflammatory or autoimmune diseases or the study of allergies.

GenOway rat models

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Several types of rats depending on the desired application:
• GFP: post-transcription cell monitoring
• BTK KO: study of the malignancy of B lymphomas
• SDRG: immunodeficient rats for tumour transplantation and studies of infectious and inflammatory diseases